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_ue_org_tagname="style" _ue_div_style="1"></div> <div> <p><b>涓€銆佹鍐袋/b></p> <p>鍖诲閬椾紶瀛︽暀鐮斿鎷ユ湁涓€鏀勾榫勩€佸鍘嗐€佺煡璇嗙粨鏋勫悎鐞嗙殑瀛︾闃熶紞锛岀幇鏈変笓鑱屾暀甯?浜猴紝鍏朵腑楂樼骇鑱岀О3浜猴紝涓骇鑱岀О3浜猴紝鍏朵腑鍗氬+4浜猴紝纭曞+1浜恒€傜洰鍓嶄富瑕佹壙鎷呭尰瀛︾敓鐨勫尰瀛﹂仐浼犲銆佸尰瀛﹂仐浼犲瀹為獙銆佺粏鑳炵敓鐗╁鍜屽尰瀛︾敓鐗╁鍥涢棬璇剧殑鏁欏浠诲姟锛屾湰瀛︾鎷ユ湁鍒嗗瓙閬椾紶瀛﹀拰缁嗚優鐢熺墿瀛︽妧鏈钩鍙帮紝鑳芥弧瓒崇鐮斿伐浣滅殑鍩烘湰闇€瑕侊紝鐜版湁澶氫釜绋冲畾鐨勭爺绌舵柟鍚戯紝杩戝勾鏉ヤ富缂栨垨鍙傜紪鍥藉绾ц鍒掓暀鏉愩€婂尰瀛﹂仐浼犲銆嬨€併€婂尰瀛︾粏鑳炵敓鐗╁銆嬨€併€婂尰瀛︾敓鐗╁銆嬬瓑10閮ㄦ暀鏉愶紝鎵挎媴鍥藉鑷劧绉戝鍩洪噾銆佺渷鍗敓鍘呰祫鍔╅」鐩瓑澶氶」鍥藉绾с€佺渷閮ㄧ骇绉戠爺椤圭洰锛屽湪鍥藉唴澶栭珮姘村钩鏈熷垔鍙戣〃璁烘枃鏁板崄绡囷紝鑾峰緱鐪佹暀鑲插巺绉戞妧鎴愭灉涓€绛夊鍜岀渷鍗敓鍘呯鎶€鎴愭灉涓夌瓑濂栥€傚湪鏁欏绉戠爺鐨勫悓鏃讹紝鏁欑爺瀹ゅ澶栧紑灞曟煋鑹蹭綋妫€鏌ャ€侀仐浼犵梾閴村畾銆侀仐浼犲挩璇㈢瓑椤圭洰宸叉湁30澶氬勾锛屽彂鐜扮殑涓変釜寮傚父鏍稿瀷缁忎腑鍥藉尰瀛﹂仐浼犲鍥藉閲嶇偣瀹為獙瀹ら壌瀹氫负涓栫晫棣栨鎶ラ亾鐨勪汉绫绘煋鑹蹭綋寮傚父鏍稿瀷銆侟/p> <p> </p> <p><b>浜孅/b><b>銆?/b><b>鏁欏宸ヤ綔</b></p> <p><b>1.</b><b>寮€璁捐绋婞/b>锛氬尰瀛﹂仐浼犲鏁欑爺瀹ゆ壙鎷呬簡鏈鐢熴€佺爺绌剁敓銆佷笓鍗囨湰绛夊悇灞傛鏁欏浠诲姟銆備负鍖诲瀛︾鍚勪笓涓氭湰绉戝鐢熷紑璁句簡鍖诲閬椾紶瀛︺€佸尰瀛﹂仐浼犲瀹為獙銆佺粏鑳炵敓鐗╁鍜屽尰瀛︾敓鐗╁绛夎绋嬶紝涓虹爺绌剁敓寮€璁句簡鍖诲閬椾紶瀛︺€佸尰瀛﹀垎瀛愰仐浼犲銆佺粏鑳炵敓鐗╁鐨勮绋嬨€傚叾涓紝缁嗚優鐢熺墿瀛﹀凡寮€灞曞弻璇暀瀛︺€傚尰瀛﹂仐浼犲鍜岀粏鑳炵敓鐗╁鍗冲皢涓虹暀瀛︾敓寮€璁惧叏鑻辫绋嬨€侟/p> <p><b> </b></p> <p><b>2.</b><b>鏁欏鏂规硶鍜屽绉戝缓璁近/b>锛氭湰瀛︾鍦ㄦ暀瀛︽敼闈╀笌瀹炶返涓ぇ鑳嗘帰绱紝鍕囦簬瀹炶返锛屾敞閲嶈繍鐢ㄧ幇浠e寲鐨勬暀瀛︽墜娈靛拰鏁欏鏂规硶锛屾繁鍙楀鐢熺殑骞挎硾娆㈣繋锛屾暀瀛︽晥鏋滀紭鑹紝澶氫汉娆″湪鏍℃暀瀛﹁川閲忓璇勬瘮涓幏濂栥€傛壙鎷呭椤规牎鏁欐敼椤圭洰鍙婂ぇ瀛︾敓鐮旂┒璁粌璁″垝椤圭洰绛夛紝鍙戣〃鏁欏璁烘枃澶氱瘒銆傚绉戞敞閲嶆暀鏉愬缓璁撅紝澶氫綅鏁欏笀鍏堝悗鍙傜紪浜嗘櫘閫氶珮绛夋暀鑲测€滃崄涓€鈥濅簲鍥藉绾ц鍒掓暀鏉愩€婂尰瀛︾敓鐗╁銆嬨€佸叏鍥介珮绛夊尰鑽櫌鏍¤鍒掓暀鏉愩€婂尰瀛﹂仐浼犲銆嬪拰銆婂尰瀛︾粏鑳炵敓鐗╁銆嬬瓑浜烘皯鍗敓鍑虹増绀俱€佺瀛﹀嚭鐗堢ぞ绛夊嚭鐗堝彂琛岀殑璁鸿憲鏁欐潗10閮ㄣ€侟/p> <p><b> </b></p> <p><b>3.</b><b>甯堣祫闃熶紞锛欬/b>鍖诲閬椾紶瀛︽暀鐮斿鐜版湁鍦ㄧ紪鏁欏笀6浜猴紝鍏朵腑鍓暀鎺?浜猴紝璁插笀3浜猴紱4浣嶅叿鏈夊崥澹浣嶏紙鍏朵腑鍗氬+鍚?浜猴級锛屼腑闈掑勾鏁欏笀锛?5宀佷互涓嬶級鍗?3%銆傛槸涓€鏀珮瀛﹀巻銆佸勾杞诲寲銆佸鏈粨鏋勫悎鐞嗙殑鍥㈤槦銆侟b></b></p> <p> </p> <p><b>涓夈€佸鏈爺绌迭/b></p> <p><b>1.</b><b>鐮旂┒鏂瑰悜</b>锛氭湰鏁欑爺瀹ゅ鏈皵姘涙祿鍘氾紝涓昏鐮旂┒鏂瑰悜鏈堻/p> <p><a name="_GoBack"></a>(1)浜虹被甯歌閬椾紶鐥呯殑妫€娴嬩笌鍜ㄨ銆傛瘮濡傚攼姘忕患鍚堢棁锛孴urner缁煎悎鐥囷紝鍘熷彂闂粡锛屽皯绮俱€佹棤绮惧瓙鐥囩瓑銆侟/p> <p>(2)鑲跨槫鐩稿叧鐨勮浆褰曞洜瀛愬湪鑲跨槫鍙戠敓鍙戝睍涓殑浣滅敤銆侟/p> <p>(3)缁翠粬鍛終浠h阿寰幆鐩稿叧鍩哄洜鐨勪綔鐢ㄦ満鐞嗭紝浠ュ強杩欎簺鍩哄洜涓庝复搴婂嚭琛€鎴栧嚌琛€寮傚父鐨勫叧绯汇€侟/p> <p>(4)鑲跨槫鐩稿叧淇″彿浼犲閫氳矾鍦ㄨ偪鐦ゅ彂鐢熷彂灞曡繃绋嬬殑鐨勪綔鐢ㄥ強鑽墿闈剁偣鐨勫紑鍙戙€侟/p> <p><b> </b></p> <p><b>2.</b><b>閮ㄥ垎鍙傜爺椤圭洰锛欬/b></p> <p>(1)HIF1 璋冩帶SCD1 鐨勬満鍒跺強鍏跺湪鑲濈檶涓殑浣滅敤鐮旂┒锛?1301076锛夛紝鍥藉鑷劧绉戝鍩洪噾锛屾矆鍥芥皯涓绘寔锛屾矆婊燂紝璧垫檽鍙備笌銆侟/p> <p>(2)瑙f暣鍚堢礌-閲戝睘铔嬬櫧閰禔DAM8鍦ㄨ倽缁嗚優鐧屽彂鐢熷彂灞曚腑鐨勪綔鐢ㄦ満鍒剁爺绌讹紙81201558锛夛紝鍥藉鑷劧绉戝鍩洪噾锛屾矆鍥芥皯鍙備笌銆侟/p> <p>(3)蹇冭倢钀ュ吇绱犲闃垮皵鍏规捣榛樼梾杞熀鍥犳ā鍨嬪皬榧犺剳缁勭粐鑳介噺浠h阿鐨勪綔鐢ㄥ強鏈哄埗鐮旂┒锛圲1304806锛夛紝鍥藉鑷劧绉戝鍩洪噾锛屾矆鍥芥皯鍙備笌銆侟/p> <p>(4)浜屾阿榛勯叜鏌氱毊鑻峰闃垮皵鑼ㄦ捣榛樼梾绐佽Е绾跨矑浣撳姛鑳介殰纰嶇殑浣滅敤鍙婃満鍒剁爺绌讹紙81601225锛夛紝鍥藉鑷劧绉戝鍩洪噾锛屾矆鍥芥皯锛屾浌闈掑弬涓庛€侟/p> <p>锛?锛夎儼鑵虹檶缁嗚優涓璫-Src婵€閰惰皟鎺otch-1娲诲寲鐨勫垎瀛愭満鍒讹紙30873033锛夛紝鍥藉鑷劧绉戝鍩洪噾锛屽垬娴╁弬涓嶞/p> <p>锛?锛塏otch瀹舵棌鍥涚铔嬬櫧璐ㄥ湪鑳拌吅鐧岀粏鑳炲熀鍥犵粍鐨勯澏鍩哄洜璋卞拰璋冩帶鏈哄埗鐨勬瘮杈冪爺绌讹紙81372156锛夛紝鍥藉鑷劧绉戝鍩洪噾锛屽垬娴╁弬涓嶞/p> <p><b>3.</b><b>閮ㄥ垎浠h〃鎬ц鏂囷細</b></p> <p>Xu, X., et al., Analysis of pupylation of Streptomyces hygroscopicus 5008 in vitro.Biochemical& Biophysical Research Communications, 2016. 474(1): p. 126-130.</p> <p>Xu, X.#, Y. Niu, K. Liang, J. Wang, X. Li and Y. Yang*. Heat shock transcription factor 未 32 is targeted for degradation via an ubiquitin-like protein ThiS in Escherichia coli. Biochemical and biophysical research communications 2015, 459 (2): 240-245.</p> <p>Cao Q, Zhang X, Lu L, Yang L, Gao J, Gao Y, Ma H, Cao Y*. (2012) Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. Development 139:3950-3961. </p> <p>Gao Y, Cao Q, Lu L, Zhang X, Zhang Z, Dong X, Jia W, Cao Y*. (2015) Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning.Development Dynamics. 244(10):1328-46. </p> <p>Lu L, Gao Y, Zhang Z, Cao Q, Zhang X, Zou J, Cao Y*.(2015)  Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear 尾-Catenin.Development Cell. 33(6):660-74. </p> <p align="left">GuominShen, NingNing, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang, Ran Zhao, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, Yinji Jin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li. Adipose differentiation-related protein (ADRP) is not involved in hypoxia inducible factor-1(HIF1) induced lipid accumulation under hypoxia. Molecular Medicine Reports. 2015 Dec;12(6):8055-61</p> <p align="left">GuominShen, XiaoboLi, Yong-fengJia, Gary APiazza, YaguangXi. Hypoxia-regulated microRNAs in human cancer.ActaPharmacol Sin.2013, Mar; 34(3):336-341</p> <p>Guo-Min Shen, Ying-Ze Zhao, Ming-Tai Chen, Feng-Lin Zhang, Xiao-Ling Liu, Yi Wang, Chang-Zheng Liu, Jia Yu, Jun-Wu Zhang. Hypoxia Inducible Facter 1 (HIF1) Promotes LDL and VLDL Uptake Through Inducing VLDLR Under Hypoxia. Biochem J, 2012, Jan; 441(2):675-683 </p> <p>Guo-Min Shen, Feng-Lin Zhang, Xiao-Ling Liu, Jun-Wu Zhang. Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia. FEBS Lett. 2010, 584(20):4366-4372</p> <p>YuanLiu,YanSHEN,HeLi,HuiWang,Zhen-RongYang,YanChen,Yan-Ping Tang.Intergeneration CAG expansion in a Wuhan juvenile-onset Huntington disease family.NeuroscienceBulietin,July 30,2007,23(4):198-202 </p> <p>Shi, C., Ma, Y., Liu, H. et al. The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cellsMol Cell Biochem (2012) 362: 65. doi:10.1007/s11010-011-1128-3</p> <p>娌堟粺锛岀瓑.rsTRAIL璇卞鐧借鐥呯粏鑳炵郴HL60鍑嬩骸鍙婂叾浣滅敤鏈哄埗.灞变笢鍖昏嵂锛?007骞?7鏈烖/p> <p>璧垫檽锛岀瓑锛?6,X,t(X;5;6)(p11.2;q35;q16)涓€渚嬨€傘€婁腑鍗庡尰瀛﹂仐浼犲鏉傚織銆?008骞?鏈圏/p> <p>璧垫檽锛岀瓑锛涙煋鑹蹭綋鑷傚唴鍊掍綅2渚嬨€傘€婁腑鍗庡尰瀛﹂仐浼犲鏉傚織銆?008骞?鏈圏/p> <p>璧垫檽锛岀瓑锛涙煋鑹蹭綋鍊掍綅浼翠笉鑹敓鑲?渚嬨€傘€婁腑鍥戒紭鐢熶笌閬椾紶鏉傚織銆?008骞?鏈圏/p> <p>璧垫檽锛岀瓑锛?31渚嬪師鍙戞€ч棴缁忓コ鎬х殑缁嗚優閬椾紶瀛﹀垎鏋?鍚笘鐣岄鎶ュ紓甯告牳鍨?渚?.閬椾紶,2008骞寸8鏈 锛圗I鏀跺綍锛堻/p> <p>璧垫檽锛岀瓑锛涗腑鍥戒汉缇ょ綏浼€婃槗浣嶆惡甯﹁€呯殑鏍稿瀷鍒嗗竷涓庣敓鑲叉儏鍐靛垎鏋愩€傘€婁腑鍥藉骞间繚鍋ユ潅蹇椼€嬶紝2011锛?6鍗饵/p> <p>璧垫檽锛岀瓑锛 t(7;15)涓€瀹剁郴3渚嬨€傘€婁腑鍗庡尰瀛﹂仐浼犲鏉傚織銆嬶紝2015骞?0鏈圏/p> <p> </p> <p><b>4.</b><b>閮ㄥ垎绉戠爺鎴愭灉锛欬/b></p> <p>(1)46,X,t(X;5;6)(p11.2;q35;q16)锛?007骞?鏈堢敱涓浗鍖诲閬椾紶瀛﹀浗瀹堕噸鐐瑰疄楠屽閴村畾涓轰笘鐣岄娆℃姤閬撶殑浜虹被鏌撹壊浣撳紓甯告牳鍨嬶紙璧垫檽锛堻/p> <p>(2)46,X,t(X;1)(q22;p34)锛 2007骞?2鏈堢敱涓浗鍖诲閬椾紶瀛﹀浗瀹堕噸鐐瑰疄楠屽閴村畾涓轰笘鐣岄娆℃姤閬撶殑浜虹被鏌撹壊浣撳紓甯告牳鍨嬶紙璧垫檽锛堻/p> <p>(3)46,XX,t(4; 9)(q21;p22),t(6;10)(p25;q25),t(11;14)(q23;q32)锛?007骞?2鏈堢敱涓浗鍖诲閬椾紶瀛﹀浗瀹堕噸鐐瑰疄楠屽閴村畾涓轰笘鐣岄娆℃姤閬撶殑浜虹被鏌撹壊浣撳紓甯告牳鍨嬶紙璧垫檽锛堻/p> <p align="left">(4)浜虹被鎸囨帉鐨偆宓寸汗涓庢櫤鍔涘彂鑲茬殑鐩稿叧鎬х爺绌躲€?998骞磋幏娌冲崡鐪佺鎶€杩涙涓夌瓑濂栵紝娌堟粺绗笁鍚 </p> <p>(5)鍖诲鐢熸€х煡璇嗘按骞崇殑鐮旂┒銆?999骞磋幏鐪佸崼鐢熷巺绉戞妧鎴愭灉涓夌瓑濂栵紝娌堟粺绗笁鍚岦/p> <p>(6)瓒崇汗涓庢櫤鍔涘彂鑲茬殑鐩稿叧鎬х爺绌躲€?001骞磋幏鐪佸崼鐢熷巺绉戞妧鎴愭灉涓夌瓑濂栵紝娌堟粺绗洓鍚岦/p> <p>(7)楗闄愬埗瀵瑰ぇ榧犲涔犺蹇嗐€佹姉姘у寲鑳藉姏鍙婄绮掗叾娲绘€у奖鍝嶇殑瀹為獙鐮旂┒銆?014骞磋幏娌冲崡鐪佹暀鑲插巺绉戞妧鎴愭灉涓€绛夊锛屾矆婊熺涓夊悕</p> <p>(8)2007骞?鏈堟寚瀵煎鐢熻幏绗?灞婃寫鎴樻澂娌冲崡鐪佸ぇ瀛︾敓璇惧瀛︽湳绉戞妧浣滃搧绔炶禌涓夌瓑濂栵紙璧垫檽锛堻/p> <p> </p> <p></p> </div></td> </tr> </table></DIV><!-- AspNetPager V6.0.0 for VS2005 End --></DIV></DIV></DIV></DIV></DIV><script src="/dfiles/11375/js/jquery-1.3.1.js" type="text/javascript"></script><script src="/dfiles/11375/js/wwwzzjsnet.js" type="text/javascript"></script><LINK rel="stylesheet" href="/dfiles/11375/main/css/iconfont.css"> <DIV class="footer" style="width: 102%;height: 195px"> <DIV class="inner" style="width: 1200px;height: 140px"> <DIV class="link-box" frag="闈㈡澘99"> <DIV frag="绐楀彛99"> 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